Bioderived Antimicrobial Fabric Coatings

A. Argun
Giner, Inc., Massachusetts, United States

Keywords: Antimicrobial coatings, phage, fabric, textile, skin pathogens

Textiles provide a favorable environment for colonization of harmful bacteria that cause problems such as odor, dermatitis, cellulitis, and other skin irritations. With growing awareness of the health risks, easy-to-apply, durable and safe coatings are sought for fabrics to provide protection and improve the quality of life of soldiers and field workers in general. Current treatments can impart antimicrobial functionality; however, they all possess broad-spectrum antimicrobial activity, affecting all skin bacteria. Bioderived antimicrobial coatings offer selective elimination of targeted bacteria without affecting bacteria required for skin health. There is considerable interest in using phages, the viruses of bacteria, to control pathogenic bacterial populations. They can uniquely offer specificity against targeted bacteria. By judicious selection of phages and host matrices, we have developed robust antimicrobial coatings with high efficacy and bacterial selectivity. Using a novel, water-based processing method, we have constructed a series of biocompatible coatings. Our phage-based coating has achieved log-killing efficacy of over 3-log (>99.9%) against S. aureus with a target-to-commensal selectivity of over 3000:1. A wide array of textile segments can benefit from this application that provides advanced fabrics to armed services, field workers, and athletics.