Replacing bacterial culture with a microchip - - next generation of rapid diagnostics

M.Weber, H.Markewich, D.Viazanko, MO'Connor, J. Mevorach
Fluid-Screen, Inc., Massachusetts, United States

Keywords: rapid diagnostic, portable, broad-spectrum pathogen detection, fluid matrices

The WHO estimates that by 2050 infectious disease will result in 13 million deaths worldwide (1). This is of concern to the U.S Department of Defense (DOD) since there will be continuous deployment of units in areas endemic for infectious diseases, with far reaching economical and social implications. Therefore, whether caring for patients or responding to a worldwide pandemic rapid and accurate diagnostics are critical technology needs of the DOD. Fluid-Screen, Inc. has a patented technology based out of research conducted at Yale University that enables rapid, portable, and accurate broad-spectrum pathogen detection in fluids. The technology is able to capture multiple bacterial species in minutes and release them simultaneously for bacterial concentration and exchange from complex matrices to defined buffer media. Once concentrated, bacteria can be detected using standard identification techniques, or the proprietary Fluid-Screen pathogen sensor designed to target either specific species of concern or a broad base of indicator bacteria. Additionally, overall bacterial loads can be determined using this technology. Here we describe the current technology status as per microorganism and fluid matrices tested and discuss the implications as relevant to national security. 1. World Health Organization. 2013. Mortality and global health estimates