Light Responsive Porous Materials for Biological Threat Mitigation

Randy W. Larsen, Lukasz Wojtas
University of South Florida, Florida, United States

Keywords: Metal Organic Materials, Drug Delivery, Photodynamic Therapy

Biological weapons of mass destructions (BioWMDs) remain a critical threat to military personnel, civilian populations and infrastructure (agricultural and livestock). Current technologies targeting BioWMDs threats include novel antibiotics, bioactive peptides, and advanced detection assays. Here, a novel platform is described to deliver a broad spectrum response against a variety of biological threats using sunlight as a stimuli to initiate the response. The new broad spectrum light response materials are composed of porous metal organic frameworks (MOFs) containing encapsulated [Ru(II)(2,2’-bipyridine)2BRA2]n+ complexes (BRA = bio-response agent: antibiotic, protein inhibitor, DNA intercalator, etc) and [Ru(II)L3]n+ complexes (for 1O2 production). The [Ru(II)(2,2’-bipyridine)2BRA2]n+ type complexes release the BRA upon excitation of the complex to the metal-to-ligand charge transfer state. The released BRA then diffuses out of the solid state material and is available to target the biological threat agent. Several prototype materials will be presented including MOFs containing Ru(II) complexes with BRA = inhibitory neurotransmitter aminobutyric acid, potassium channel blocker 4-aminopyridine, nitric oxide, and amino acid analogs . The results presented here serve as a starting point for the development of more advance light responsive materials to mitigate the effects of deployed BioWMDs.