Bio-scaffolds for regeneration of damaged brain tissue

AFFILIATION:   Fabrico Technology, Georgetown, Texas, United States


Track: Medical & Biotech
Area: Bioderived & Bioinspired Materials
Tech Readiness: TRL 3

Tech Brief: We plan to develop a biocompatible scaffold which when seeded with the patients stem cells can regenerate and restore brain function in severely injured brain tissue. Currently is NO treatment for brain tissue which has been damaged by penetrating and closed head wounds.


Value Proposition: Combat deaths and long-term disability result from a myriad of causes and the overwhelming majority of combat zone deaths occur prior to reaching any medical treatment facility. The two major causes of death are (1) hemorrhage and (2) traumatic brain injury (TBI). IEDs)account for over 50% of combat related deaths in Iraq. Brain ricocheting inside the skull during impact inflicts the most damage resulting in haematomas (ruptured blood vessels, lesions), voids in tissue due to neuron degeneration, scar tissue formation, release of inhibitory axon growth factors, and failure of neurons to initiate axon regeneration. Treatment strategies for these type of injuries are aimed at minimizing further injury, as the initial brain damage is irreversible. Immediate treatments focus on ensuring oxygen supply to the brain, maintaining blood flow and controlling blood pressure by using medications. For the most severely injured patients additional surgery to remove haematomas, repair of contusions and finally removal to extensively damaged brain tissue is performed by highly skilled neurosurgeons. Currently there is NO treatment that would restore and regenerate damaged brain tissue. Our ECM technology would provide a means to provide a treatment to restore brain function and rehabilitate severely injured warfighters.


Org Type: Early-stage Startup (Seed)